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Genetics

Genes and Environmental Risks Are the Real Cause of Disease

A quote from the Gene Environment Interaction Fact Sheet [1] from the Centers for Disease Control states that virtually all human… “…diseases result from the interaction of genetic susceptibility factors and modifiable environmental factors, broadly defined to include...
The Age of Genetics

The Age of Genetics

Ever since I was a bright-eyed and bushy tailed medical student, roaming the hallowed halls of the University of Virginia Medical School over 40 years ago, the mantra of modern medicine was drilled into my head, that all disease is caused by two factors – genetic...

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Genetic Testing – A New Way to Influence How Kids Turn Out?

Genetic Testing – A New Way to Influence How Kids Turn Out?

A famous best-seller, The Nurture Assumption: Why Children Turn Out the Way They Do, by psychologist Judith Rich Harris, has been circulating for 20 years.  Based on amassed studies, parental influences on children matter a lot less than peer group influences, and they both matter less than genetic factors.  Parents are advised to not blame themselves if their children don’t become Rhodes scholars, because controlling peer group influences is difficult and controlling genetic expression is impossible.  Until the last few years, parents were expected to do the best they can to control the friends that their children hang out with, and hope that their children’s genes will line up well enough to someday produce a productive, happy member of society.

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How to Find Out About Your Genetic Risks

How to Find Out About Your Genetic Risks

A human being’s genetic blueprint is housed in our 23 chromosomes which is where the name of the genetic test “23andMe” gets its name. Each of our 23 chromosomes has an average of about 1000 genes, and each gene has an average of about 100 quirky substitutions, which are sometimes referred to as mutations or polymorphisms. These millions of quirky substitutions partly explains why we are all so delightfully unique in the way we look, think, act and feel about life’s challenges. Most of these mutations or polymorphisms are not considered to be detrimental, but a handful could be important under certain circumstances and cause serious diseases and other health problems, which is why it is important to know about them.

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Methylation 102: A Deeper Look at the MTHFR Gene

Methylation 102: A Deeper Look at the MTHFR Gene

Given the exuberant response to the article Methylation 101: What it Means for Your Health, I have been encouraged to write a second article to continue the discussion.  In the first article, I introduced the idea that those with “methylation defects” are relatively less capable of methylating away the fight/flight neurotransmitter noradrenalin and are thus likely to incur a more heightened and sustained stress response from stressors of any cause. Having a heightened tendency to be motivated by extra stress, the up-side of having methylation defects can compel such people to have increased drive to succeed and be more productive!

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